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1 article(s) from Tzakos, Andreas G

On the design principles of peptide–drug conjugates for targeted drug delivery to the malignant tumor site

Eirinaios I. Vrettos,
Gábor Mező and
Andreas G. Tzakos

Beilstein J. Org. Chem. 2018, 14, 930–954, doi:10.3762/bjoc.14.80

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Graphical Abstract

Figure 1: Conventional chemotherapy versus targeted chemotherapy. Black color = Solid malignant tumor; red = ...

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Figure 2: A. General structural architecture of the ideal navigated drug delivery system [31]. B. General structu...

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Figure 3: Binding and penetration mechanism of iRGD. The iRGD peptide is accumulated on the surface of αv int...

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Figure 4: Representative examples of anticancer drugs utilized for the construction of PDCs. The most usual c...

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Figure 5: Illustration of the drug release mechanism from the self-immolative spacer PABC conjugated to a tum...

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Figure 6: Structures of the PDCs named AN-152 and AN-207.

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Figure 7: Structure of the PDC named AN-238.

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Figure 8: Chemical structure and synthetic scheme for the PDC ANG1005. (A) ANG1005 is composed of three molec...

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Figure 9: Structure of oxime linked Dau–GnRH-III conjugate with or without cathepsin B labile spacer and thei...

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Figure 10: Synthesis of the most effective GnRH-III–Dau conjugate with two drug molecules [153].

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Figure 11: Structures of the four different PDCs of D-Lys⁶-GnRH-I and gemcitabine (GSG, GSG₂, 3G, 3G₂) [19].

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Figure 12: Structures of (A) native sunitinib; (B) SAN1 analog of sunitinib and (C) assembled PDC named SAN1GS...

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Figure 13: Synthetic scheme for the formation of GSG and the unexpected side product [156].

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Figure 14: Illustration of uncharted guanidinium peptide coupling reagent side reactions during PDCs synthesis ...

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Figure 15: Putative mechanism for the formation of the uronium side product [156].

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Review

Published 26 Apr 2018

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